COA student Weronika Grabowska is a co-author on a paper detailing the roles that exercise and genetics play with regards to neurovascular aging in mice. The piece shows that exercise from middle to older age preserves the cerebrovascular health, prevents behavioral deficits and reduces age-related neuroinflammation in the cortex and hippocampus in aged mice. Mice deficient in APOE, a gene associated with longevity and Alzheimer’s disease, are resistant to the beneficial effects of exercise, suggesting a possible mediating role for APOE in the maintenance and function of the neurovascular system during aging. The paper appeared in the peer-reviewed journal, PLOS Biology.

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